tickBoosts energy
tickMuscle Builder
tickStrength enhancer
How does it work?
Dubbed by some as the "new" creatine, NO2 is one of the most popular supplements in the United States. Used 30 minutes prior to a workout, NO2 gives users a "perpetual pump" that lasts long after the workout is over. Its effect on nitric oxide synthesis also means that bodybuilders using NO2 regularly for several weeks usually gain both muscle size and strength.

Per capsule:
Arginine Alpha-Ketoglutarate: 1000 milligrams
Niacin: 20 milligrams
Glucose: 50 milligrams
How does it work?
Arginine Alpha-Ketoglutarate
Arginine Alpha-Ketoglutarate acts to stimulate the production of nitric oxide in your body. Nitric oxide acts as your body's master "cell-signalling" molecule, directing and ordering a complex array of activities. It regulates blood flow, muscle contraction, nerve signalling and muscle growth, to name just a few [3]. The functions of this molecule are very impressive. However, you can't just go out and buy nitric oxide (known also as NO). Instead, you use Arginine Alpha-Ketoglutarate, which is a natural, non-drug method of creating NO in the human body. Arginine has been shown to increase NO production in blood vessels, where it widens their diameter, increasing blood flow without elevating blood pressure. Wider blood vessels carry more blood to muscles and tissues, delivering increased amounts of protein, carbohydrate and the various anabolic hormones (such as growth hormone and testosterone) needed for muscle growth. When nitric oxide is present in the muscles, it activates “gene-expression” and turns on the body's muscle-building mechanism (commonly called protein synthesis).

The most obvious and immediate benefit of extra NO is the enhanced "pump." Some bodybuilders report that their pumps were far larger and lasted longer. They looked bigger. Their muscles felt fuller and tighter. Some of them literally felt pumped all day. But the pump is really only a side effect. The real benefit is the ability of NO to rapidly generate new muscle growth, increase strength and accelerate recovery in all of the muscles - the small as well as the larger ones. Scientists still don't why, but NO stimulates protein synthesis in the muscle. That protein then goes on to form muscle tissue.

Plain arginine supplements (or even red meat, which is rich in arginine) won't produce the same results. For a supplement to be effective at boosting nitric oxide levels continuously, it needs to have some kind of extended-release delivery system. This is achieved by combining Arginine with Alpha-Ketoglutarate. Arginine also boosts the production of growth hormone. Human growth hormone helps in muscle building, leading to increased muscle size and strength. Growth hormone also decreases body fat. Arginine is a very popular treatment for erectile dysfunction, and has a reputation for restoring sex drive and confidence [1, 2].

Niacin (also called vitamin B3) is one of eight water-soluble B vitamins. All B vitamins help the body convert carbohydrates into sugar, which is "burned" to produce energy. Niacin plays an important role in ridding the body of toxic and harmful chemicals. It also helps the body make various sex and stress-related hormones in the adrenal glands and other parts of the body.

Glucose is also known as a monosaccharide. It can be absorbed into the bloodstream through the lining of your intestines, and helps to increase the uptake and absorption of Niacin and Arginine Alpha-Ketoglutarate.
How do I use it?
For optimum results, take 2-4 tablets 30 minutes before training. This will increase muscle pump and fullness. You can also take 2 tablets 3 times a day with a creatine-based product (such as Creatamax 8000GL) to aid muscle growth.
What results can I expect?
Most bodybuilders report greater pumps - not just during the workout, but throughout the day - when NO2 is taken before exercise. NO2 also accelerates muscle growth, though the effects are not instant, and take 20-30 days to become apparent. Some people may also notice a strong increase in libido when using this product.

1. Gonzalez-Cadavid NF, Rajfer J. (2000). Therapeutic stimulation of penile nitric oxide synthase (NOS) and related pathways. Drugs Today, 36, 163-174
2. Moody JA, Vernet D, Laidlaw S, Rajfer J, Gonzalez-Cadavid NF. (1997). Effects of long-term oral administration of L-arginine on the rat erectile response. Journal of Urology, 158, 942-947
3. Grange RW, Isotani E, Lau KS, Kamm KE, Huang PL, Stull JT. (2001). Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch muscles. Physiological Genomics, 5, 35-44

Buy Related Products from a Trusted Seller

Reflex Creapure Creatine Monohydrate<br />£16.49Met-RX NOS Arginine Alpha-Ketoglutarate<br />£39.99San T3 Guggulsterones<br />£17.99ZMA Testosterone Booster<br />£13.99
Reflex Creapure Creatine Monohydrate
Met-RX NOS Arginine Alpha-Ketoglutarate
San T3 Guggulsterones
ZMA Testosterone Booster

This article is protected by international copyright protection ©2020.
Do not use this copy without reading this first

Click here to see the references for this article

Download FREE eBooks

How you can pack on lean muscle and lose body fat fast...

If you're not sure of how to train or what to eat or even which supplements are best for your goals, we're organised a special promotion from Musclebulletin, who are offering their £3.99 excellent 32 page book, 'The secrets to getting into shape' free to all Nutriline visitors. You'll find their information on how to pack on muscle, burn fat and succeed in your sport invaluable and easy to understand and follow.


The Secrets of Getting Into Shape

Shows you how to train, eat and even sleep for maximum results. Everything from choosing a gym, training programmes, diet plans... to which supplements are best for packing on muscle size and losing body fat is covered - without the long waffle and boredom of 300-page 'fitness' books, that you never end up finishing! The style is to the point, easy to read and understand, and guarantees results!

The Easy Way to Achieving Awesome abs...

Frustrated at not seeing your abs, embarrassed about taking your top of at the beach this summer or the local swimming pool? Is your belly holding a layer of flab that is making you look like a beached whale or are you just trying to lose that extra layer of fat to ensure you look the best you can?

Zef Eisenberg sports nutrition and training expert and founder of Maximuscle has agreed to offer you his FREE booklet from his science publications collection to all Muscle Bulletin subscribers on; how to train, diet, eat and which supplements to take and more on getting an awesome set of abs.

Just fill in the form below and we'll email you straight away with download details. We hate spam as much as you do and don't share your email address with anyone.