(Known as Black pepper, Piperine, Bioperine™)

tickAids health
How does it work?
Bioperine® is a standardized piperine extract obtained from the fruits of the black pepper and/or long pepper plants. It has little effect on weight loss, lean muscle gain or sporting performance. Rather, the main effect of Bioperine® is to enhance the bioavailability of various nutrients consumed with it [1].

Who is it used for?
Bioperine® is suitable for anyone who wants to increase the bioavailability and absorption of the supplements they use.
How does it work?
The sensation of warmth in the mouth after consuming black pepper is primarily due to the presence of the alkaloid piperine, which was isolated at the beginning of the 19th century by the German scientist Derstad. Bioperine® is a standardized piperine extract obtained from the fruits of the black pepper and/or long pepper plants that are cultivated in the damp, nutrient-rich soil regions of south India. The delicate pepper berries are hand harvested prior to ripening and then sun dried.

Bioperine® has been clinically tested in the United States and shown to significantly enhance the bioavailability of supplemented nutrients through increased absorption [2]. Studies show that Bioperine® increases the absorption of coenzyme Q10 by approximately 30% [1], with some trials demonstrating a 20-fold increase in bioavailability [3]. Bioperine® also has several U.S. patents as a bioavailability enhancer (including # 5,536,506, # 5,744,161 and # 5,972,382). The only clinical studies done with piperine for nutritional purposes are with Bioperine®.
How do I use it?
Approximately 2-5 milligrams of Bioperine® is needed to enhance the bioavailability and absorption of nutrients consumed with it. What results should I expect? Bioperine® will enhance the bioavailability of co-administered nutrients by 30% or more.
What can it be combined with?
Some of the nutrients which may be co-administered with Bioperine® include herbal extracts (such as Curcumin, Boswellia serrata, Ashwagandha, Ginkgo biloba and Capsaicin), water-soluble vitamins (such as Vitamin B1, Vitamin B2, Niacin, Vitamin B6, Vitamin B12, Folic acid and Vitamin C), fat-soluble vitamins (including Vitamin A, Vitamin D, Vitamin E, and Vitamin K), amino acids (lysine, isoleucine, leucine, threonine, valine, tryptophan, phenylalanine, and methionine) and various minerals (including calcium, iron, zinc, vanadium, selenium, chromium, iodine, potassium, manganese, copper and magnesium).

1. Badmaev, V. V., Majeed, M., & Prakash, L. (2000). Piperine derived from black pepper increases the plasma levels of coenzyme q10 following oral supplementation. Journal of Nutritional Biochemistry, 11, 109-113
2. Velpandian, T., Jasuja, R., Bhardwaj, R.K., Jaiswal, J., & Gupta, S.K. (2001). Piperine in food: interference in the pharmacokinetics of phenytoin. European Journal of Drug Metabolism and Pharmacokinetics, 26, 241-247
3. Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., & Srinivas, P.S. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica, 64, 353-356 -

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