(Known as GAKIC, Glycine-l-arginine-alpha-ketoisocaproic acid)

tickPart of the Amino Acid group
tickMuscle Builder
tickStrength enhancer
What is GAKIC?

Glycine-l-arginine-alpha-ketoisocaproic acid (GAKIC) is a safe and natural blend of amino acids that is commonly used by bodybuilders, gym users and athletes to combat muscle fatigue, maintain muscle force during workouts and increase training intensity. Because GAKIC is supported by significant scientific research to offer immediate results when taken before intense exercise, it′s considered one of the best safe and natural training and performance aids available.

How does GAKIC work?

Intense weight training or exercise involving intense power output (such as sprinting) causes a rapid build-up of intra-muscular toxins - particularly ammonia which quickly increases the pH of muscle tissue. Unfortunately, the result is fatigue and a rapid decline in muscle power, strength and endurance (for example, the fatigue experienced when performing heavy barbell squats).

The key function of GAKIC is to enhance the body′s capacity to remove ammonia from muscle cells. The nutrients in GAKIC are thought to activate a muscle enzyme called
l-leucine dehydrogenase, which in turn increases ammonia removal via the production of the amino acid l-leucine.

Because GAKIC immediately increasing the body′s capacity to buffer muscle toxins, GAKIC offers gym users and athletes a way of rapidly increasing their performance and training intensity (unlike creatine, GAKIC does not need ′loading′ for several days). The ability to perform more repetitions and lift heavier weights is likely to significantly increase long-term muscle growth and strength development.

Each component of GAKIC displays specific nutritional properties that may benefit high intensity performance, training intensity and muscle growth:


Arginine is a multi-functional nutrient, but plays a role in the excretion of ammonia from muscle cells. Since ammonia is known to cause acute muscle fatigue, the arginine in GAKIC may have significant effects in reducing fatigue. Arginine also promotes hormone production and nitric oxide synthesis, which may aid muscle pumps and nutrient delivery.

Alpha-ketoisocaproate (KIC)

KIC is a branched-chain keto acid (BCKA) that has the capacity to remove ammonia from muscle tissue during ATP energy metabolism. The combination of arginine and KIC is believed to be very effective in reducing muscle toxins and buffering metabolic acids. In addition, KIC′s anti-catabolic action help to prevent muscle breakdown and aid long-term muscle development.


The latest research shows that growth hormone synthesis increases proportionally with the intake of the amino acid glycine [1]. Because growth hormone is considered a factor in muscle growth, part of GAKIC′s benefits may be due to elevated growth hormone levels.

How effective is GAKIC?

The current GAKIC research supports the view that the nutrient enhances resistance to fatigue and increases workout capacity.

Researchers at the University of Florida conducted a double-blind, randomized, crossover-study, comparing the effects of glycine-l-arginine-alpha-ketoisocaproic acid calcium (aka GAKIC) vs. a placebo (9.46 g sucrose) before resistance training on a knee extension machine. GAKIC was found to increase resistance to fatigue by 28%, and elevate muscle work by 10.5%, during a 15 minute workout [1].

This data may translate into real results in the gym. For example, if you can perform 8 reps with 80kg, GAKIC may enable you to lift the same weight 10 times (approximately 28% more resistance to fatigue).

Further research has reported that glycine-l-arginine-alpha-ketoisocaproic acid prevents fatigue-induced power reduction during cycle sprints, supporting the benefits of GAKIC as a muscle power and workout aid [2].

Another benefit of GAKIC supplementation is the nutrient′s rapid effects, which according to scientific research, can be experienced by consuming the supplement prior to exercise (i.e. you do not need to wait days to feel GAKIC working). This makes GAKIC a promising, non-stimulant pre-workout nutrient. Since GAKIC need only be taken on workout days, it′s also likely to appeal to trainers on a budget.

Who can benefit from GAKIC?

GAKIC is increasingly being used by a wide range of gym users, bodybuilders, athletes and sports players. Essentially, the nutrient may be useful for anyone performing high intensity exercise (such as weight trainers, bodybuilders, sprinters, boxers, football players and even endurance runners for bursts of power). GAKIC can be used as both a performance aid, and a muscle and strength builder ∼ depending on your goals.

How do I take GAKIC?

To get the performance effects detailed in research studies, it′s recommended to consume 8-10g of GAKIC 30 minutes before training. The effects of GAKIC are rapid, so there is no need to load the nutrient or take a serving on rest days. If you are considering using GAKIC, it is essential to use a full potency brand containing the genuine ingredients. GAKIC can be taken alone, but it can also be found in some cutting-edge pre-workout products where it is stacked with other research proven anti-fatigue nutrients such as creatine, beta alanine, histidine and citrulline malate.

What results can I expect from GAKIC?

Most GAKIC users experience a greater workout capacity the first time they use the supplement (GAKC is designed to work immediately when taken 30 minutes pre-workout). If you are training for muscle mass, by enabling significantly more reps in every set, GAKIC is likely to enable more productive workouts and subsequently more muscle growth over weeks and months.

1. Stevens BR, Godfrey MD, Kaminski TW, Braith RW (2000) High-intensity dynamic human muscle performance enhanced by a metabolic intervention. Med Sci Sports Exerc, 32:2102-2108
2. Buford BN, Koch AJ (2004) Glycine-arginine-ketoisocaproic acid improves performance of repeated cycling sprints. Med Sci Sports Exerc, 36:583-587

Buy Related Products from a Trusted Seller

L-CitrullinePrimaFORCE Citrulline MalateL-Citrulline Malate ComplexAlpha Lipoic Acid<br />$21.41
L-CitrullinePrimaFORCE Citrulline MalateL-Citrulline Malate ComplexAlpha Lipoic Acid

This article is protected by international copyright protection ©2020.
Do not use this copy without reading this first

Click here to see the references for this article

Download FREE eBooks

How you can pack on lean muscle and lose body fat fast...

If you're not sure of how to train or what to eat or even which supplements are best for your goals, we're organised a special promotion from Musclebulletin, who are offering their £3.99 excellent 32 page book, 'The secrets to getting into shape' free to all Nutriline visitors. You'll find their information on how to pack on muscle, burn fat and succeed in your sport invaluable and easy to understand and follow.


The Secrets of Getting Into Shape

Shows you how to train, eat and even sleep for maximum results. Everything from choosing a gym, training programmes, diet plans... to which supplements are best for packing on muscle size and losing body fat is covered - without the long waffle and boredom of 300-page 'fitness' books, that you never end up finishing! The style is to the point, easy to read and understand, and guarantees results!

The Easy Way to Achieving Awesome abs...

Frustrated at not seeing your abs, embarrassed about taking your top of at the beach this summer or the local swimming pool? Is your belly holding a layer of flab that is making you look like a beached whale or are you just trying to lose that extra layer of fat to ensure you look the best you can?

Zef Eisenberg sports nutrition and training expert and founder of Maximuscle has agreed to offer you his FREE booklet from his science publications collection to all Muscle Bulletin subscribers on; how to train, diet, eat and which supplements to take and more on getting an awesome set of abs.

Just fill in the form below and we'll email you straight away with download details. We hate spam as much as you do and don't share your email address with anyone.